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Reviewed March 2013
What is the official name of the APC gene?
The official name of this gene is “adenomatous polyposis coli.”
APC is the gene's official symbol. The APC gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the APC gene?
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It helps control how often a cell divides, how it attaches to other cells within a tissue, and whether a cell moves within or away from a tissue. This protein also helps ensure that the number of chromosomes in a cell is correct following cell division. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling.
One protein with which APC associates is beta-catenin. Beta-catenin helps control the activity (expression) of particular genes and promotes the growth and division (proliferation) of cells and the process by which cells mature to carry out specific functions (differentiation). Beta-catenin also helps cells attach to one another and is important for tissue formation. Association of APC with beta-catenin signals for beta-catenin to be broken down when it is no longer needed.
How are changes in the APC gene related to health conditions?
Genetics Home Reference provides information about primary macronodular adrenal hyperplasia, which is also associated with changes in the APC gene.
Where is the APC gene located?
Cytogenetic Location: 5q21-q22
Molecular Location on chromosome 5: base pairs 112,707,504 to 112,846,238
The APC gene is located on the long (q) arm of chromosome 5 between positions 21 and 22.
More precisely, the APC gene is located from base pair 112,707,504 to base pair 112,846,238 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about APC?
You and your healthcare professional may find the following resources about APC helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the APC gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding APC?
acids ; amino acid ; benign ; breakdown ; cancer ; cell ; cell division ; colon ; colorectal ; connective tissue ; deletion ; desmoid ; differentiation ; DNA ; familial ; gastric ; gene ; hyperplasia ; inherited ; isoleucine ; lysine ; medulloblastoma ; mutation ; polyposis ; proliferation ; protein ; sporadic ; stomach ; syndrome ; tissue ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (16 links)