|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed April 2014
What is the official name of the AMN gene?
The official name of this gene is “amnion associated transmembrane protein.”
AMN is the gene's official symbol. The AMN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AMN gene?
The AMN gene provides instructions for making a protein called amnionless. This protein is involved in the uptake of vitamin B12 (also called cobalamin) from food. Vitamin B12, which cannot be made in the body and can only be obtained from food, is essential for the formation of DNA and proteins, the production of cellular energy, and the breakdown of fats. This vitamin is involved in the formation of red blood cells and maintenance of the brain and spinal cord (central nervous system).
The amnionless protein is primarily found embedded in the outer membrane of kidney cells and cells that line the small intestine. Amnionless attaches (binds) to another protein called cubilin, anchoring cubilin to the cell membrane. Cubilin can interact with molecules and proteins passing through the intestine or kidneys. During digestion, vitamin B12 is released from food. As the vitamin passes through the small intestine, cubilin binds to it. Amnionless helps transfer the cubilin-vitamin B12 complex into the intestinal cell. From there, the vitamin is released into the blood and transported throughout the body. In the kidneys, amnionless and cubilin are involved in the reabsorption of certain proteins that would otherwise be released in urine.
How are changes in the AMN gene related to health conditions?
Where is the AMN gene located?
Cytogenetic Location: 14q32.3
Molecular Location on chromosome 14: base pairs 102,922,548 to 102,930,847
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The AMN gene is located on the long (q) arm of chromosome 14 at position 32.3.
More precisely, the AMN gene is located from base pair 102,922,548 to base pair 102,930,847 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AMN?
You and your healthcare professional may find the following resources about AMN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AMN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AMN?
anemia ; breakdown ; cell ; cell membrane ; central nervous system ; cobalamin ; digestion ; DNA ; endocytosis ; gene ; intestine ; kidney ; megaloblastic anemia ; nervous system ; neurological ; precursor ; protein ; proteinuria ; syndrome ; transmembrane ; vitamin B12
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.