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Reviewed August 2010
What is the official name of the ALOXE3 gene?
The official name of this gene is “arachidonate lipoxygenase 3.”
ALOXE3 is the gene's official symbol. The ALOXE3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ALOXE3 gene?
The ALOXE3 gene provides instructions for making an enzyme called eLOX3. This enzyme is part of a family of enzymes called lipoxygenases. Most enzymes in this family help add an oxygen molecule to certain fatty acids to produce substances called fatty acid hydroperoxides.
Unlike other lipoxygenases, the eLOX3 enzyme does not act directly on fatty acids. Instead, it processes the product of another lipoxygenase reaction, a fatty acid hydroperoxide. The substance produced is later converted to a signaling molecule that is involved in the growth and division (proliferation) and specialization (differentiation) of skin cells.
The eLOX3 enzyme is thought to play a role in the formation and maintenance of the fat (lipid) membrane of the cells that make up the outermost layer of the skin (the epidermis). The epidermis helps prevent water loss, regulates body temperature, and protects against infection.
Does the ALOXE3 gene share characteristics with other genes?
The ALOXE3 gene belongs to a family of genes called ALOX (arachidonate lipoxygenases).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ALOXE3 gene related to health conditions?
Where is the ALOXE3 gene located?
Cytogenetic Location: 17p13.1
Molecular Location on chromosome 17: base pairs 8,095,900 to 8,118,916
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ALOXE3 gene is located on the short (p) arm of chromosome 17 at position 13.1.
More precisely, the ALOXE3 gene is located from base pair 8,095,900 to base pair 8,118,916 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ALOXE3?
You and your healthcare professional may find the following resources about ALOXE3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ALOXE3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ALOXE3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.