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Reviewed June 2008
What is the official name of the ALDH7A1 gene?
The official name of this gene is “aldehyde dehydrogenase 7 family member A1.”
ALDH7A1 is the gene's official symbol. The ALDH7A1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ALDH7A1 gene?
The ALDH7A1 gene is a member of the aldehyde dehydrogenase (ALDH) gene family. These genes provide instructions for producing enzymes that alter molecules called aldehydes. The ALDH7A1 gene provides instructions for making an enzyme called α-aminoadipic semialdehyde (α-AASA) dehydrogenase, also known as antiquitin. Within the cell, antiquitin is found in the internal fluid of the cell (cytosol) and in the nucleus. This enzyme is involved in the breakdown of the protein building block (amino acid) lysine in the brain. In one step in the breakdown of lysine to other molecules, antiquitin facilitates the conversion of α-aminoadipic semialdehyde to α-aminoadipate. The breakdown of lysine in the brain is necessary for energy production and to produce other needed molecules.
Does the ALDH7A1 gene share characteristics with other genes?
The ALDH7A1 gene belongs to a family of genes called ALDH (aldehyde dehydrogenases).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ALDH7A1 gene related to health conditions?
Where is the ALDH7A1 gene located?
Cytogenetic Location: 5q31
Molecular Location on chromosome 5: base pairs 126,541,841 to 126,595,390
The ALDH7A1 gene is located on the long (q) arm of chromosome 5 at position 31.
More precisely, the ALDH7A1 gene is located from base pair 126,541,841 to base pair 126,595,390 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ALDH7A1?
You and your healthcare professional may find the following resources about ALDH7A1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ALDH7A1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ALDH7A1?
acids ; aldehyde ; aldehydes ; amino acid ; breakdown ; cell ; cytosol ; deficiency ; dehydrogenase ; enzyme ; epilepsy ; gene ; glutamine ; glycine ; lysine ; mutation ; neurotransmitters ; nucleus ; protein
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.