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Reviewed May 2013
What is the official name of the AGTR1 gene?
The official name of this gene is “angiotensin II receptor, type 1.”
AGTR1 is the gene's official symbol. The AGTR1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AGTR1 gene?
The AGTR1 gene provides instructions for making a protein called the angiotensin II receptor type 1 (AT1 receptor). This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. Through a series of steps, the renin-angiotensin system produces a molecule called angiotensin II, which attaches (binds) to the AT1 receptor, stimulating chemical signaling. This signaling causes blood vessels to narrow (constrict), which results in increased blood pressure. Binding of angiotensin II to the AT1 receptor also stimulates production of the hormone aldosterone, which triggers the absorption of water and salt by the kidneys. The increased amount of fluid in the body also increases blood pressure. Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures.
Does the AGTR1 gene share characteristics with other genes?
The AGTR1 gene belongs to a family of genes called GPCR (G protein-coupled receptors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the AGTR1 gene related to health conditions?
Where is the AGTR1 gene located?
Cytogenetic Location: 3q24
Molecular Location on chromosome 3: base pairs 148,697,870 to 148,743,002
The AGTR1 gene is located on the long (q) arm of chromosome 3 at position 24.
More precisely, the AGTR1 gene is located from base pair 148,697,870 to base pair 148,743,002 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AGTR1?
You and your healthcare professional may find the following resources about AGTR1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AGTR1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AGTR1?
adenine ; aldosterone ; complication ; cytosine ; diabetes ; DNA ; dysgenesis ; gene ; hormone ; hypertension ; hypotension ; kidney ; molecule ; nephropathy ; nucleotide ; oxygen ; protein ; proximal ; receptor ; renal
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.