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AGT
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AGT

The information on this page was automatically extracted from online scientific databases.

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What is the official name of the AGT gene?

The official name of this gene is “angiotensinogen (serpin peptidase inhibitor, clade A, member 8).”

AGT is the gene's official symbol. The AGT gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the AGT gene?

From Entrez GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

NOTE: UniProtThis link leads to a site outside Genetics Home Reference. suggests using caution when interpreting this information.

How are changes in the AGT gene related to health conditions?

UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the AGT gene's known or predicted involvement in human disease.

Essential hypertension (EHT)[1]This link leads to a site outside Genetics Home Reference.: A condition in which blood pressure is consistently higher than normal with no identifiable cause. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Renal tubular dysgenesis (RTD)[2]This link leads to a site outside Genetics Home Reference.: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.

Entrez GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the AGT gene.
  • Essential hypertension[1]This link leads to a site outside Genetics Home Reference.
  • Renal dysplasia[2]This link leads to a site outside Genetics Home Reference.
UniProt and Entrez Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number		Main Topic
[1]145500This link leads to a site outside Genetics Home Reference.HYPERTENSION, ESSENTIAL
[2]267430This link leads to a site outside Genetics Home Reference.RENAL TUBULAR DYSGENESIS
106150This link leads to a site outside Genetics Home Reference.ANGIOTENSINOGEN

Where is the AGT gene located?

Cytogenetic Location: 1q42.2

Molecular Location on chromosome 1: base pairs 230,838,268 to 230,850,335

The AGT gene is located on the long (q) arm of chromosome 1 at position 42.2.

The AGT gene is located on the long (q) arm of chromosome 1 at position 42.2.

More precisely, the AGT gene is located from base pair 230,838,268 to base pair 230,850,335 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about AGT?

You and your healthcare professional may find the following resources about AGT helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the AGT gene or gene products?

  • ANHU
  • SERPINA8

See How are genetic conditions and genes named? in the Handbook.

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding AGT?

adrenal cortex ; aldosterone ; atrial ; atrial fibrillation ; autosomal ; autosomal recessive ; cardiac ; dysgenesis ; dysplasia ; enzyme ; expressed ; familial ; fibrillation ; gene ; homeostasis ; hypertension ; hypoplasia ; ligand ; mutation ; nervous system ; phenotype ; platelets ; polymorphism ; protein ; pulmonary ; RAS ; receptor ; recessive ; renal ; sodium ; susceptibility ; vascular

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: May 20, 2013