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Reviewed January 2016
What is the official name of the AGPAT2 gene?
The official name of this gene is “1-acylglycerol-3-phosphate O-acyltransferase 2.”
AGPAT2 is the gene's official symbol. The AGPAT2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AGPAT2 gene?
The AGPAT2 gene provides instructions for making an enzyme that is found in many of the body's cells and tissues. It plays a critical role in the growth and development of adipocytes, which are cells that store fats for energy. Adipocytes are the major component of the body's fatty (adipose) tissue.
The AGPAT2 enzyme is part of a chemical pathway in many cells that produces two important types of fats (lipids): glycerophospholipids and triacylglycerols. Glycerophospholipids are the major component of cell membranes and are involved in chemical signaling within cells. Triacylglycerols (also known as triglycerides) are fat molecules that are stored in adipocytes for later conversion to energy.
The AGPAT2 enzyme is responsible for a particular chemical reaction in the production of these two types of lipids. Specifically, the enzyme helps convert a molecule called lysophosphatidic acid (LPA) to another molecule, phosphatidic acid (PA). Additional reactions convert phosphatidic acid to glycerophospholipids and triacylglycerols.
How are changes in the AGPAT2 gene related to health conditions?
Where is the AGPAT2 gene located?
Cytogenetic Location: 9q34.3
Molecular Location on chromosome 9: base pairs 136,673,143 to 136,687,459
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The AGPAT2 gene is located on the long (q) arm of chromosome 9 at position 34.3.
More precisely, the AGPAT2 gene is located from base pair 136,673,143 to base pair 136,687,459 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AGPAT2?
You and your healthcare professional may find the following resources about AGPAT2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AGPAT2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AGPAT2?
adipocytes ; adipose tissue ; cell ; cell membrane ; congenital ; diabetes ; diabetes mellitus ; differentiation ; enzyme ; gene ; hypertriglyceridemia ; lipodystrophy ; molecule ; phosphate ; tissue ; triglycerides
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.