|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed June 2009
What is the official name of the ADGRG1 gene?
The official name of this gene is “adhesion G protein-coupled receptor G1.”
ADGRG1 is the gene's official symbol. The ADGRG1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ADGRG1 gene?
The ADGRG1 gene, formerly known as GPR56, provides instructions for making a protein that is critical for normal brain development. Before birth, the ADGRG1 protein appears to be essential for the normal growth and movement (migration) of nerve cells (neurons) in a part of the brain called the cerebral cortex. This outer layer of the brain carries out many important functions, such as sensation, voluntary muscle movement, thought, planning, and memory.
Although the ADGRG1 protein has been studied most extensively in the brain, it is active in many of the body's tissues. This protein interacts with other proteins on the cell surface to trigger a series of chemical signals within the cell. Studies suggest that ADGRG1 signaling may play an important role in attaching cells to one another (cell adhesion).
Does the ADGRG1 gene share characteristics with other genes?
The ADGRG1 gene belongs to a family of genes called GPCR (G protein-coupled receptors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ADGRG1 gene related to health conditions?
Where is the ADGRG1 gene located?
Cytogenetic Location: 16q21
Molecular Location on chromosome 16: base pairs 57,619,535 to 57,665,039
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ADGRG1 gene is located on the long (q) arm of chromosome 16 at position 21.
More precisely, the ADGRG1 gene is located from base pair 57,619,535 to base pair 57,665,039 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ADGRG1?
You and your healthcare professional may find the following resources about ADGRG1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ADGRG1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ADGRG1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.