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Reviewed April 2013
What is the official name of the ACTG1 gene?
The official name of this gene is “actin gamma 1.”
ACTG1 is the gene's official symbol. The ACTG1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ACTG1 gene?
The ACTG1 gene provides instructions for making a protein called gamma (γ)-actin, which is part of the actin protein family. Proteins in this family are organized into a network of fibers called the actin cytoskeleton, which makes up the structural framework inside cells. There are six types of actin; four are present only in muscle cells, where they are involved in the tensing of muscle fibers (muscle contraction). The other two actin proteins, γ-actin and beta (β)-actin (produced from the ACTB gene), are found in cells throughout the body. These proteins play important roles in determining cell shape and controlling cell movement (motility).
γ-actin is particularly abundant in certain cells in the intestines and the inner ear. Within the inner ear, this protein is found in specialized cells called hair cells, which are essential for normal hearing.
How are changes in the ACTG1 gene related to health conditions?
Where is the ACTG1 gene located?
Cytogenetic Location: 17q25
Molecular Location on chromosome 17: base pairs 81,509,971 to 81,512,866
The ACTG1 gene is located on the long (q) arm of chromosome 17 at position 25.
More precisely, the ACTG1 gene is located from base pair 81,509,971 to base pair 81,512,866 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ACTG1?
You and your healthcare professional may find the following resources about ACTG1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ACTG1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ACTG1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.