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Reviewed April 2013
What is the official name of the ACTB gene?
The official name of this gene is “actin, beta.”
ACTB is the gene's official symbol. The ACTB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ACTB gene?
The ACTB gene provides instructions for making a protein called beta (β)-actin, which is part of the actin protein family. Proteins in this family are organized into a network of fibers called the actin cytoskeleton, which makes up the structural framework inside cells. There are six types of actin; four are present only in muscle cells, where they are involved in the tensing of muscle fibers (muscle contraction). The other two actin proteins, β-actin and gamma (γ)-actin (produced from the ACTG1 gene), are found in cells throughout the body. These proteins play important roles in determining cell shape and controlling cell movement (motility). Studies suggest that β-actin may also be involved in relaying chemical signals within cells.
How are changes in the ACTB gene related to health conditions?
Where is the ACTB gene located?
Cytogenetic Location: 7p22
Molecular Location on chromosome 7: base pairs 5,527,148 to 5,530,601
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ACTB gene is located on the short (p) arm of chromosome 7 at position 22.
More precisely, the ACTB gene is located from base pair 5,527,148 to base pair 5,530,601 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ACTB?
You and your healthcare professional may find the following resources about ACTB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ACTB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ACTB?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.