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Reviewed December 2013
What is the official name of the ACP5 gene?
The official name of this gene is “acid phosphatase 5, tartrate resistant.”
ACP5 is the gene's official symbol. The ACP5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ACP5 gene?
The ACP5 gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells. Osteopontin performs a variety of functions in these cells. Two versions (isoforms) of the TRAP enzyme are produced: TRAP5a is found primarily in immune cells and TRAP5b is found primarily in bone cells called osteoclasts.
Osteoclasts are specialized cells that break down and remove (resorb) bone tissue that is no longer needed. These cells are involved in bone remodeling, which is a normal process that replaces old bone tissue with new bone. During bone remodeling, osteopontin is turned on (activated), allowing osteoclasts to attach (bind) to bones. When the breakdown of bone is complete, TRAP5b turns off (inactivates) osteopontin, causing the osteoclasts to release themselves from bone.
In the immune system, osteopontin is found primarily in cells called macrophages and dendritic cells. The protein helps fight infection by promoting inflammation, regulating immune cell activity, and turning on various immune system cells that are necessary to fight off foreign invaders such as bacteria and viruses. Like TRAP5b in bone cells, the TRAP5a enzyme inactivates osteopontin in macrophages and dendritic cells when it is no longer needed.
How are changes in the ACP5 gene related to health conditions?
Where is the ACP5 gene located?
Cytogenetic Location: 19p13.2
Molecular Location on chromosome 19: base pairs 11,574,660 to 11,578,986
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ACP5 gene is located on the short (p) arm of chromosome 19 at position 13.2.
More precisely, the ACP5 gene is located from base pair 11,574,660 to base pair 11,578,986 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ACP5?
You and your healthcare professional may find the following resources about ACP5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ACP5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ACP5?
acids ; autoimmune ; bacteria ; bone remodeling ; breakdown ; cell ; dephosphorylation ; disability ; enzyme ; gene ; immune system ; infection ; inflammation ; isoforms ; phosphatase ; protein ; short stature ; stature ; susceptibility ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.