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Reviewed May 2013
What is the official name of the ACE gene?
The official name of this gene is “angiotensin I converting enzyme.”
ACE is the gene's official symbol. The ACE gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ACE gene?
The ACE gene provides instructions for making the angiotensin-converting enzyme. This enzyme is able to cut (cleave) proteins. It is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. By cutting a protein called angiotensin I at a particular location, the angiotensin-converting enzyme converts this protein to angiotensin II. Angiotensin II causes blood vessels to narrow (constrict), which results in increased blood pressure. This protein also stimulates production of the hormone aldosterone, which triggers the absorption of salt and water by the kidneys. The increased amount of fluid in the body also increases blood pressure. Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures.
The angiotensin-converting enzyme can cleave other proteins, including bradykinin. Bradykinin causes blood vessels to widen (dilate), which decreases blood pressure. Cleavage by the angiotensin-converting enzyme inactivates bradykinin, helping to increase blood pressure.
Does the ACE gene share characteristics with other genes?
The ACE gene belongs to a family of genes called CD (CD molecules).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ACE gene related to health conditions?
Where is the ACE gene located?
Cytogenetic Location: 17q23.3
Molecular Location on chromosome 17: base pairs 63,477,061 to 63,498,380
The ACE gene is located on the long (q) arm of chromosome 17 at position 23.3.
More precisely, the ACE gene is located from base pair 63,477,061 to base pair 63,498,380 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ACE?
You and your healthcare professional may find the following resources about ACE helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ACE gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ACE?
aldosterone ; allele ; bradykinin ; deletion ; diabetes ; DNA ; dysgenesis ; enzyme ; gene ; genetic variation ; hemorrhage ; hemorrhagic stroke ; hormone ; hypotension ; insertion ; intracerebral hemorrhage ; kidney ; nephropathy ; oxygen ; polymorphism ; protein ; proximal ; renal ; risk factors ; susceptibility ; transcript
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.