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Reviewed March 2009
What is the official name of the ABCC2 gene?
The official name of this gene is “ATP binding cassette subfamily C member 2.”
ABCC2 is the gene's official symbol. The ABCC2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ABCC2 gene?
The ABCC2 gene provides instructions for producing a protein called multidrug resistance protein 2 (MRP2). This protein is one of a family of multidrug resistance proteins involved in the transport of substances out of cells. MRP2 is primarily found in the liver, with smaller amounts in the kidneys, intestine, and placenta.
MRP2 transports a variety of substances out of cells. For example, MRP2 clears certain drugs from organs and tissues, playing a part in drug metabolism. Drug metabolism involves the breakdown of drugs into different chemical components allowing the drugs to have their intended effects and eventually be eliminated from the body. MRP2 also transports a substance called bilirubin out of liver cells and into bile (a digestive fluid produced by the liver). Bilirubin is produced during the breakdown of old red blood cells and has an orange-yellow tint.
Does the ABCC2 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ABCC2 gene related to health conditions?
Where is the ABCC2 gene located?
Cytogenetic Location: 10q24
Molecular Location on chromosome 10: base pairs 99,782,598 to 99,852,576
The ABCC2 gene is located on the long (q) arm of chromosome 10 at position 24.
More precisely, the ABCC2 gene is located from base pair 99,782,598 to base pair 99,852,576 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ABCC2?
You and your healthcare professional may find the following resources about ABCC2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ABCC2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ABCC2?
acids ; amino acid ; anion ; arginine ; ATP ; bile ; bilirubin ; breakdown ; cancer ; cell ; digestive ; excretion ; gene ; glutathione ; histidine ; intestine ; isoleucine ; jaundice ; metabolism ; mutation ; phenylalanine ; placenta ; population ; protein ; syndrome ; xenobiotics
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (14 links)