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Genetics Home Reference: your guide to understanding genetic conditions
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X-linked dystonia-parkinsonism

Reviewed December 2008

What is X-linked dystonia-parkinsonism?

X-linked dystonia-parkinsonism is a movement disorder that has been found only in people of Filipino descent. This condition affects men much more often than women.

Parkinsonism is usually the first sign of X-linked dystonia-parkinsonism. Parkinsonism is a group of movement abnormalities including tremors, unusually slow movement (bradykinesia), rigidity, an inability to hold the body upright and balanced (postural instability), and a shuffling gait that can cause recurrent falls.

Later in life, many affected individuals also develop a pattern of involuntary, sustained muscle contractions known as dystonia. The dystonia associated with X-linked dystonia-parkinsonism typically starts in one area, most often the eyes, jaw, or neck, and later spreads to other parts of the body. The continuous muscle cramping and spasms can be disabling. Depending on which muscles are affected, widespread (generalized) dystonia can cause difficulty with speaking, swallowing, coordination, and walking.

The signs and symptoms of X-linked dystonia-parkinsonism vary widely. In the mildest cases, affected individuals have slowly progressive parkinsonism with little or no dystonia. More severe cases involve dystonia that rapidly becomes generalized. These individuals become dependent on others for care within a few years after signs and symptoms appear, and they may die prematurely from breathing difficulties, infections (such as aspiration pneumonia), or other complications.

How common is X-linked dystonia-parkinsonism?

X-linked dystonia-parkinsonism has been reported in more than 500 people of Filipino descent, although it is likely that many more Filipinos are affected. Most people with this condition can trace their mother's ancestry to the island of Panay in the Philippines. The prevalence of the disorder is 5.24 per 100,000 people on the island of Panay.

What genes are related to X-linked dystonia-parkinsonism?

Mutations in and near the TAF1 gene can cause X-linked dystonia-parkinsonism. The TAF1 gene provides instructions for making part of a protein called transcription factor IID (TFIID). This protein is active in cells and tissues throughout the body, where it plays an essential role in regulating the activity of most genes.

The TAF1 gene is part of a complex region of DNA known as the TAF1/DYT3 multiple transcript system. This region consists of short stretches of DNA from the TAF1 gene plus some extra segments of genetic material near the gene. These stretches of DNA can be combined in different ways to create various sets of instructions for making proteins. Researchers believe that some of these variations are critical for the normal function of nerve cells (neurons) in the brain.

Several changes in the TAF1/DYT3 multiple transcript system have been identified in people with X-linked dystonia-parkinsonism. Scientists are uncertain how these changes are related to the movement abnormalities characteristic of this disease. However, they suspect that the changes disrupt the regulation of critical genes in neurons. This defect leads to the eventual death of these cells, particularly in areas of the brain called the caudate nucleus and putamen. These regions are critical for normal movement, learning, and memory. It is unclear why the effects of changes in the TAF1/DYT3 multiple transcript system appear to be limited to dystonia and parkinsonism.

Related Gene(s)

Changes in this gene are associated with X-linked dystonia-parkinsonism.

  • TAF1

How do people inherit X-linked dystonia-parkinsonism?

This condition is inherited in an X-linked recessive pattern. The gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation typically must occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, males are affected by X-linked recessive disorders much more frequently than females. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.

In X-linked recessive inheritance, females with one altered copy of the gene in each cell are called carriers. They can pass on the gene to their children, but they usually do not experience signs and symptoms of the disorder. However, a few females carrying one altered copy of the TAF1 gene have developed movement abnormalities associated with X-linked dystonia-parkinsonism. These movement problems tend to be milder than those seen in affected men, and they are usually not progressive or disabling.

Where can I find information about diagnosis or management of X-linked dystonia-parkinsonism?

These resources address the diagnosis or management of X-linked dystonia-parkinsonism and may include treatment providers.

  • Gene Review: X-Linked Dystonia-Parkinsonism Syndrome (http://www.ncbi.nlm.nih.gov/books/NBK1489/)
  • Genetic Testing Registry: Dystonia 3, torsion, X-linked (http://www.ncbi.nlm.nih.gov/gtr/conditions/C1839130)

You might also find information on the diagnosis or management of X-linked dystonia-parkinsonism in Educational resources (http://ghr.nlm.nih.gov/condition/x-linked-dystonia-parkinsonism/show/Educational+resources) and Patient support (http://ghr.nlm.nih.gov/condition/x-linked-dystonia-parkinsonism/show/Patient+support).

General information about the diagnosis (http://ghr.nlm.nih.gov/handbook/consult/diagnosis) and management (http://ghr.nlm.nih.gov/handbook/consult/treatment) of genetic conditions is available in the Handbook. Read more about genetic testing (http://ghr.nlm.nih.gov/handbook/testing), particularly the difference between clinical tests and research tests (http://ghr.nlm.nih.gov/handbook/testing/researchtesting).

To locate a healthcare provider, see How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

Where can I find additional information about X-linked dystonia-parkinsonism?

You may find the following resources about X-linked dystonia-parkinsonism helpful. These materials are written for the general public.

You may also be interested in these resources, which are designed for healthcare professionals and researchers.

What other names do people use for X-linked dystonia-parkinsonism?

  • Dystonia 3, torsion, X-linked
  • dystonia musculorum deformans
  • Dystonia-parkinsonism, X-linked
  • DYT3
  • Lubag
  • Torsion dystonia-parkinsonism, Filipino type
  • XDP
  • X-linked dystonia-parkinsonism syndrome
  • X-linked torsion dystonia-parkinsonism syndrome

For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines (http://ghr.nlm.nih.gov/ConditionNameGuide) and How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What if I still have specific questions about X-linked dystonia-parkinsonism?

Ask the Genetic and Rare Diseases Information Center (http://rarediseases.info.nih.gov/GARD/).

What glossary definitions help with understanding X-linked dystonia-parkinsonism?

bradykinesia ; caudate ; caudate nucleus ; cell ; chromosome ; DNA ; dystonia ; gait ; gene ; inheritance ; involuntary ; mutation ; nucleus ; parkinsonism ; pneumonia ; prevalence ; protein ; putamen ; recessive ; retrotransposon ; sex chromosomes ; sign ; syndrome ; transcript ; transcription ; transcription factor ; X-linked recessive

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).

References

  • Evidente VG, Advincula J, Esteban R, Pasco P, Alfon JA, Natividad FF, Cuanang J, Luis AS, Gwinn-Hardy K, Hardy J, Hernandez D, Singleton A. Phenomenology of "Lubag" or X-linked dystonia-parkinsonism. Mov Disord. 2002 Nov;17(6):1271-7. (http://www.ncbi.nlm.nih.gov/pubmed/12465067?dopt=Abstract)
  • Evidente VG, Gwinn-Hardy K, Hardy J, Hernandez D, Singleton A. X-linked dystonia ("Lubag") presenting predominantly with parkinsonism: a more benign phenotype? Mov Disord. 2002 Jan;17(1):200-2. (http://www.ncbi.nlm.nih.gov/pubmed/11835466?dopt=Abstract)
  • Evidente VG, Nolte D, Niemann S, Advincula J, Mayo MC, Natividad FF, Müller U. Phenotypic and molecular analyses of X-linked dystonia-parkinsonism ("lubag") in women. Arch Neurol. 2004 Dec;61(12):1956-9. (http://www.ncbi.nlm.nih.gov/pubmed/15596620?dopt=Abstract)
  • Gene Review: X-Linked Dystonia-Parkinsonism Syndrome (http://www.ncbi.nlm.nih.gov/books/NBK1489/)
  • Graeber MB, Müller U. The X-linked dystonia-parkinsonism syndrome (XDP): clinical and molecular genetic analysis. Brain Pathol. 1992 Oct;2(4):287-95. Review. (http://www.ncbi.nlm.nih.gov/pubmed/1364136?dopt=Abstract)
  • Kaji R, Goto S, Tamiya G, Ando S, Makino S, Lee LV. Molecular dissection and anatomical basis of dystonia: X-linked recessive dystonia-parkinsonism (DYT3). J Med Invest. 2005 Nov;52 Suppl:280-3. (http://www.ncbi.nlm.nih.gov/pubmed/16366515?dopt=Abstract)
  • Kupke KG, Lee LV, Viterbo GH, Arancillo J, Donlon T, Müller U. X-linked recessive torsion dystonia in the Philippines. Am J Med Genet. 1990 Jun;36(2):237-42. (http://www.ncbi.nlm.nih.gov/pubmed/2368812?dopt=Abstract)
  • Lee LV, Maranon E, Demaisip C, Peralta O, Borres-Icasiano R, Arancillo J, Rivera C, Munoz E, Tan K, Reyes MT. The natural history of sex-linked recessive dystonia parkinsonism of Panay, Philippines (XDP). Parkinsonism Relat Disord. 2002 Oct;9(1):29-38. Review. (http://www.ncbi.nlm.nih.gov/pubmed/12217620?dopt=Abstract)
  • Makino S, Kaji R, Ando S, Tomizawa M, Yasuno K, Goto S, Matsumoto S, Tabuena MD, Maranon E, Dantes M, Lee LV, Ogasawara K, Tooyama I, Akatsu H, Nishimura M, Tamiya G. Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. Am J Hum Genet. 2007 Mar;80(3):393-406. Epub 2007 Jan 23. (http://www.ncbi.nlm.nih.gov/pubmed/17273961?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: December 2008
Published: April 17, 2014