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Genetics Home Reference: your guide to understanding genetic conditions     A service of the U.S. National Library of Medicine®

Mayer-Rokitansky-Küster-Hauser syndrome

Reviewed March 2015

What is Mayer-Rokitansky-Küster-Hauser syndrome?

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder that occurs in females and mainly affects the reproductive system. This condition causes the vagina and uterus to be underdeveloped or absent. Affected women usually do not have menstrual periods due to the absent uterus. Often, the first noticeable sign of MRKH syndrome is that menstruation does not begin by age 16 (primary amenorrhea). Women with MRKH syndrome have a female chromosome pattern (46,XX) and normally functioning ovaries. They also have normal female external genitalia and normal breast and pubic hair development. Although women with this condition are usually unable to carry a pregnancy, they may be able to have children through assisted reproduction.

Women with MRKH syndrome may also have abnormalities in other parts of the body. The kidneys may be abnormally formed or positioned, or one kidney may fail to develop (unilateral renal agenesis). Affected individuals commonly develop skeletal abnormalities, particularly of the spinal bones (vertebrae). Females with MRKH syndrome may also have hearing loss or heart defects.

How common is Mayer-Rokitansky-Küster-Hauser syndrome?

MRKH syndrome affects approximately 1 in 4,500 newborn girls.

What genes are related to Mayer-Rokitansky-Küster-Hauser syndrome?

The cause of MRKH syndrome is unknown, although it probably results from a combination of genetic and environmental factors. Researchers have not identified any genes associated with MRKH syndrome.

The reproductive abnormalities of MRKH syndrome are due to incomplete development of the Müllerian duct. This structure in the embryo develops into the uterus, fallopian tubes, cervix, and the upper part of the vagina. The cause of the abnormal development of the Müllerian duct in affected individuals is unknown. Originally, researchers believed that MRKH syndrome was caused by something the fetus was exposed to during pregnancy, such as a medication or maternal illness. However, studies have not identified an association with maternal drug use, illness, or other factors. It is also unclear why some affected individuals have abnormalities in parts of the body other than the reproductive system.

How do people inherit Mayer-Rokitansky-Küster-Hauser syndrome?

Most cases of MRKH syndrome occur in people with no history of the disorder in their family.

Less often, MRKH syndrome is passed through generations in families. Its inheritance pattern is usually unclear because the signs and symptoms of the condition frequently vary among affected individuals in the same family. However, in some families, the condition appears to have an autosomal dominant pattern of inheritance. Autosomal dominant inheritance means that one copy of the altered gene in each cell is typically sufficient to cause the disorder, although no genes have been associated with MRKH syndrome.

Where can I find information about diagnosis or management of Mayer-Rokitansky-Küster-Hauser syndrome?

These resources address the diagnosis or management of Mayer-Rokitansky-Küster-Hauser syndrome and may include treatment providers.

  • American Urological Association Foundation: Vaginal Agenesis (
  • Children's Hospital Boston: Center for Young Women's Health (
  • Genetic Testing Registry: Rokitansky Kuster Hauser syndrome (

You might also find information on the diagnosis or management of Mayer-Rokitansky-Küster-Hauser syndrome in Educational resources and Patient support.

General information about the diagnosis ( and management ( of genetic conditions is available in the Handbook. Read more about genetic testing (, particularly the difference between clinical tests and research tests (

To locate a healthcare provider, see How can I find a genetics professional in my area? ( in the Handbook.

Where can I find additional information about Mayer-Rokitansky-Küster-Hauser syndrome?

You may find the following resources about Mayer-Rokitansky-Küster-Hauser syndrome helpful. These materials are written for the general public.

You may also be interested in these resources, which are designed for healthcare professionals and researchers.

What other names do people use for Mayer-Rokitansky-Küster-Hauser syndrome?

  • congenital absence of the uterus and vagina (CAUV)
  • genital renal ear syndrome (GRES)
  • MRKH syndrome
  • Mullerian agenesis
  • Mullerian aplasia
  • Mullerian dysgenesis
  • Rokitansky syndrome

For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines ( and How are genetic conditions and genes named? ( in the Handbook.

What if I still have specific questions about Mayer-Rokitansky-Küster-Hauser syndrome?

Ask the Genetic and Rare Diseases Information Center (

What glossary definitions help with understanding Mayer-Rokitansky-Küster-Hauser syndrome?

agenesis ; autosomal ; autosomal dominant ; cell ; chromosome ; congenital ; duct ; dysgenesis ; embryo ; fetus ; gene ; genitalia ; inheritance ; inheritance pattern ; kidney ; maternal ; menstruation ; pattern of inheritance ; renal ; reproduction ; sign ; syndrome ; unilateral

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.


  • Guerrier D, Mouchel T, Pasquier L, Pellerin I. The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina)--phenotypic manifestations and genetic approaches. J Negat Results Biomed. 2006 Jan 27;5:1. Review. (
  • Herlin M, Højland AT, Petersen MB. Familial occurrence of Mayer-Rokitansky-Küster-Hauser syndrome: a case report and review of the literature. Am J Med Genet A. 2014 Sep;164A(9):2276-86. doi: 10.1002/ajmg.a.36652. Epub 2014 Jun 26. Review. (
  • Morcel K, Camborieux L; Programme de Recherches sur les Aplasies Müllériennes, Guerrier D. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Orphanet J Rare Dis. 2007 Mar 14;2:13. Review. (
  • Pizzo A, Laganà AS, Sturlese E, Retto G, Retto A, De Dominici R, Puzzolo D. Mayer-rokitansky-kuster-hauser syndrome: embryology, genetics and clinical and surgical treatment. ISRN Obstet Gynecol. 2013;2013:628717. doi: 10.1155/2013/628717. Epub 2013 Feb 4. (
  • Sultan C, Biason-Lauber A, Philibert P. Mayer-Rokitansky-Kuster-Hauser syndrome: recent clinical and genetic findings. Gynecol Endocrinol. 2009 Jan;25(1):8-11. doi: 10.1080/09513590802288291. Review. (
  • Wottgen M, Brucker S, Renner SP, Strissel PL, Strick R, Kellermann A, Wallwiener D, Beckmann MW, Oppelt P. Higher incidence of linked malformations in siblings of Mayer-Rokitansky-Küster-Hauser-syndrome patients. Hum Reprod. 2008 May;23(5):1226-31. doi: 10.1093/humrep/den059. Epub 2008 Mar 5. (


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? ( in the Handbook.

Reviewed: March 2015
Published: February 8, 2016