Protein binding

Protein binding

• ABCA1: ATP-binding cassette, sub-family A (ABC1), member 1
• ABCD1: ATP-binding cassette, sub-family D (ALD), member 1
• ACAT1: acetyl-Coenzyme A acetyltransferase 1
• ACTG1: actin, gamma 1
• ACVR1: activin A receptor, type I
• ACVRL1: activin A receptor type II-like 1
• ADA: adenosine deaminase
• ADAMTS13: ADAM metallopeptidase with thrombospondin type 1 motif, 13
• AGXT: alanine-glyoxylate aminotransferase
• AHCY: adenosylhomocysteinase
• AIRE: autoimmune regulator
• ALAS2: aminolevulinate, delta-, synthase 2
• ALDH5A1: aldehyde dehydrogenase 5 family, member A1
• ALS2: amyotrophic lateral sclerosis 2 (juvenile)
• AMELX: amelogenin (amelogenesis imperfecta 1, X-linked)
• ANG: angiogenin, ribonuclease, RNase A family, 5
• ANK2: ankyrin 2, neuronal
• ANTXR2: anthrax toxin receptor 2
• APC: adenomatous polyposis coli
• APOB: apolipoprotein B (including Ag(x) antigen)
• APOE: apolipoprotein E
• APP: amyloid beta (A4) precursor protein
• APTX: aprataxin
• AR: androgen receptor
• ASS1: argininosuccinate synthetase 1
• ATG16L1: ATG16 autophagy related 16-like 1 (S. cerevisiae)
• ATM: ataxia telangiectasia mutated
• ATN1: atrophin 1
• ATP2A2: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
• ATP6V0A2: ATPase, H+ transporting, lysosomal V0 subunit a2
• ATP7A: ATPase, Cu++ transporting, alpha polypeptide
• ATP7B: ATPase, Cu++ transporting, beta polypeptide
• ATRX: alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
• BARD1: BRCA1 associated RING domain 1
• BCKDHB: branched chain keto acid dehydrogenase E1, beta polypeptide
• BCOR: BCL6 co-repressor
• BLM: Bloom syndrome, RecQ helicase-like
• BMPR1A: bone morphogenetic protein receptor, type IA
• BMPR2: bone morphogenetic protein receptor, type II (serine/threonine kinase)
• BRAF: v-raf murine sarcoma viral oncogene homolog B1
• BRCA1: breast cancer 1, early onset
• BRCA2: breast cancer 2, early onset
• BRIP1: BRCA1 interacting protein C-terminal helicase 1
• BTK: Bruton agammaglobulinemia tyrosine kinase
• CACNA1A: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
• CACNA1C: calcium channel, voltage-dependent, L type, alpha 1C subunit
• CACNA1F: calcium channel, voltage-dependent, L type, alpha 1F subunit
• CACNB4: calcium channel, voltage-dependent, beta 4 subunit
• CCM2: cerebral cavernous malformation 2
• CD40LG: CD40 ligand
• CDAN1: congenital dyserythropoietic anemia, type I
• CDH1: cadherin 1, type 1, E-cadherin (epithelial)
• CDH23: cadherin-like 23
• CDKL5: cyclin-dependent kinase-like 5
• CDKN1C: cyclin-dependent kinase inhibitor 1C (p57, Kip2)
• CFTR: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
• CHEK2: CHK2 checkpoint homolog (S. pombe)
• CHN1: chimerin (chimaerin) 1
• CLDN14: claudin 14
• CLN3: ceroid-lipofuscinosis, neuronal 3
• CNBP: CCHC-type zinc finger, nucleic acid binding protein
• COL11A1: collagen, type XI, alpha 1
• COL11A2: collagen, type XI, alpha 2
• COL1A1: collagen, type I, alpha 1
• COL1A2: collagen, type I, alpha 2
• COL2A1: collagen, type II, alpha 1
• COL3A1: collagen, type III, alpha 1
• COL4A3: collagen, type IV, alpha 3 (Goodpasture antigen)
• COL5A1: collagen, type V, alpha 1
• COL7A1: collagen, type VII, alpha 1
• COMT: catechol-O-methyltransferase
• CPS1: carbamoyl-phosphate synthetase 1, mitochondrial
• CREBBP: CREB binding protein
• CSTB: cystatin B (stefin B)
• CTSA: cathepsin A
• CUL7: cullin 7
• CYP1B1: cytochrome P450, family 1, subfamily B, polypeptide 1
• D2HGDH: D-2-hydroxyglutarate dehydrogenase
• DCTN1: dynactin 1 (p150, glued homolog, Drosophila)
• DCX: doublecortin
• DDC: dopa decarboxylase (aromatic L-amino acid decarboxylase)
• DHCR7: 7-dehydrocholesterol reductase
• DMD: dystrophin
• DMPK: dystrophia myotonica-protein kinase
• DNM2: dynamin 2
• DRD3: dopamine receptor D3
• DSPP: dentin sialophosphoprotein
• EDA: ectodysplasin A
• EDAR: ectodysplasin A receptor
• EDARADD: EDAR-associated death domain
• EDN3: endothelin 3
• EFEMP2: EGF-containing fibulin-like extracellular matrix protein 2
• EGR2: early growth response 2 (Krox-20 homolog, Drosophila)
• EIF2B1: eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
• EIF2B2: eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
• EIF2B3: eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
• EIF2B4: eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
• EIF2B5: eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
• EMD: emerin
• ENG: endoglin
• EP300: E1A binding protein p300
• EPM2A: epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
• ERAP1: endoplasmic reticulum aminopeptidase 1
• ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
• ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
• ERCC8: excision repair cross-complementing rodent repair deficiency, complementation group 8
• EXT1: exostoses (multiple) 1
• EXT2: exostoses (multiple) 2
• F12: coagulation factor XII (Hageman factor)
• F2: coagulation factor II (thrombin)
• F8: coagulation factor VIII, procoagulant component
• FBLN5: fibulin 5
• FBN1: fibrillin 1
• FECH: ferrochelatase (protoporphyria)
• FGD1: FYVE, RhoGEF and PH domain containing 1
• FGFR1: fibroblast growth factor receptor 1
• FGFR2: fibroblast growth factor receptor 2
• FGFR3: fibroblast growth factor receptor 3
• FLCN: folliculin
• FLNA: filamin A, alpha
• FLT4: fms-related tyrosine kinase 4
• FMR1: fragile X mental retardation 1
• FOXL2: forkhead box L2
• FOXP3: forkhead box P3
• FTL: ferritin, light polypeptide
• FXN: frataxin
• G6PD: glucose-6-phosphate dehydrogenase
• GALE: UDP-galactose-4-epimerase
• GAN: gigaxonin
• GBA: glucosidase, beta; acid (includes glucosylceramidase)
• GCDH: glutaryl-Coenzyme A dehydrogenase
• GCH1: GTP cyclohydrolase 1
• GFAP: glial fibrillary acidic protein
• GJA1: gap junction protein, alpha 1, 43kDa
• GLA: galactosidase, alpha
• GLI3: GLI family zinc finger 3
• GNAS: GNAS complex locus
• GNPTG: N-acetylglucosamine-1-phosphate transferase, gamma subunit
• GPR56: G protein-coupled receptor 56
• GRHPR: glyoxylate reductase/hydroxypyruvate reductase
• GTF2I: general transcription factor IIi
• GTF2IRD1: GTF2I repeat domain containing 1
• HBA2: hemoglobin, alpha 2
• HBB: hemoglobin, beta
• HEXA: hexosaminidase A (alpha polypeptide)
• HEXB: hexosaminidase B (beta polypeptide)
• HPRT1: hypoxanthine phosphoribosyltransferase 1
• HRAS: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
• HSD17B10: hydroxysteroid (17-beta) dehydrogenase 10
• HSPB1: heat shock 27kDa protein 1
• HTT: huntingtin
• IGF2: insulin-like growth factor 2 (somatomedin A)
• IKBKAP: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
• IKBKG: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
• IL1A: interleukin 1, alpha
• IL2RG: interleukin 2 receptor, gamma (severe combined immunodeficiency)
• ITGB4: integrin, beta 4
• JAG1: jagged 1 (Alagille syndrome)
• JPH3: junctophilin 3
• KCNJ2: potassium inwardly-rectifying channel, subfamily J, member 2
• KCNQ1: potassium voltage-gated channel, KQT-like subfamily, member 1
• KIF1B: kinesin family member 1B
• KRAS: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
• KRIT1: KRIT1, ankyrin repeat containing
• KRT14: keratin 14
• KRT16: keratin 16
• KRT17: keratin 17
• KRT5: keratin 5
• KRT6A: keratin 6A
• LDLR: low density lipoprotein receptor
• LDLRAP1: low density lipoprotein receptor adaptor protein 1
• LETM1: leucine zipper-EF-hand containing transmembrane protein 1
• LIMK1: LIM domain kinase 1
• LITAF: lipopolysaccharide-induced TNF factor
• LMNA: lamin A/C
• LMX1B: LIM homeobox transcription factor 1, beta
• LPL: lipoprotein lipase
• LRP2: low density lipoprotein-related protein 2
• LRRK2: leucine-rich repeat kinase 2
• LYST: lysosomal trafficking regulator
• MAP2K1: mitogen-activated protein kinase kinase 1
• MAP2K2: mitogen-activated protein kinase kinase 2
• MECP2: methyl CpG binding protein 2 (Rett syndrome)
• MED12: mediator complex subunit 12
• MEFV: Mediterranean fever
• MEN1: multiple endocrine neoplasia I
• MID1: midline 1 (Opitz/BBB syndrome)
• MKKS: McKusick-Kaufman syndrome
• MLH1: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
• MMP20: matrix metallopeptidase 20
• MSH2: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
• MSH6: mutS homolog 6 (E. coli)
• MSTN: myostatin
• MSX2: msh homeobox 2
• MTHFR: 5,10-methylenetetrahydrofolate reductase (NADPH)
• MTMR2: myotubularin related protein 2
• MT-ND1: mitochondrially encoded NADH dehydrogenase 1
• MT-ND4L: mitochondrially encoded NADH dehydrogenase 4L
• MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase
• MUTYH: mutY homolog (E. coli)
• MYCN: v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
• MYO6: myosin VI
• MYO7A: myosin VIIA
• NBN: nibrin
• NCF1: neutrophil cytosolic factor 1
• NDP: Norrie disease (pseudoglioma)
• NDRG1: N-myc downstream regulated 1
• NEFL: neurofilament, light polypeptide
• NF1: neurofibromin 1
• NLRP12: NLR family, pyrin domain containing 12
• NLRP3: NLR family, pyrin domain containing 3
• NOD2: nucleotide-binding oligomerization domain containing 2
• NOTCH2: Notch homolog 2 (Drosophila)
• NOTCH3: Notch homolog 3 (Drosophila)
• NPC1: Niemann-Pick disease, type C1
• NPC2: Niemann-Pick disease, type C2
• NR0B1: nuclear receptor subfamily 0, group B, member 1
• NR5A1: nuclear receptor subfamily 5, group A, member 1
• NSD1: nuclear receptor binding SET domain protein 1
• OAT: ornithine aminotransferase (gyrate atrophy)
• PABPN1: poly(A) binding protein, nuclear 1
• PAFAH1B1: platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)
• PANK2: pantothenate kinase 2
• PARK2: Parkinson disease (autosomal recessive, juvenile) 2, parkin
• PARK7: Parkinson disease (autosomal recessive, early onset) 7
• PAX3: paired box 3
• PAX6: paired box 6
• PAX8: paired box 8
• PCBD1: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
• PCSK9: proprotein convertase subtilisin/kexin type 9
• PDCD10: programmed cell death 10
• PHOX2B: paired-like homeobox 2b
• PIGA: phosphatidylinositol glycan anchor biosynthesis, class A
• PKD1: polycystic kidney disease 1 (autosomal dominant)
• PKD2: polycystic kidney disease 2 (autosomal dominant)
• PKHD1: polycystic kidney and hepatic disease 1 (autosomal recessive)
• PLOD1: procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
• PMS2: PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
• PPP1R12A: protein phosphatase 1, regulatory (inhibitor) subunit 12A
• PRKAG2: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
• PRNP: prion protein
• PROC: protein C (inactivator of coagulation factors Va and VIIIa)
• PROK2: prokineticin 2
• PRX: periaxin
• PSEN1: presenilin 1
• PSEN2: presenilin 2 (Alzheimer disease 4)
• PTCH1: patched homolog 1 (Drosophila)
• PTEN: phosphatase and tensin homolog
• PTPN11: protein tyrosine phosphatase, non-receptor type 11
• RAB7A: RAB7A, member RAS oncogene family
• RAD50: RAD50 homolog (S. cerevisiae)
• RAD51: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
• RAF1: v-raf-1 murine leukemia viral oncogene homolog 1
• RB1: retinoblastoma 1
• RPL11: ribosomal protein L11
• RPL35A: ribosomal protein L35a
• RPL5: ribosomal protein L5
• RPS19: ribosomal protein S19
• RPS24: ribosomal protein S24
• RPS7: ribosomal protein S7
• RUNX2: runt-related transcription factor 2
• RYR1: ryanodine receptor 1 (skeletal)
• SAA1: serum amyloid A1
• SBDS: Shwachman-Bodian-Diamond syndrome
• SBF2: SET binding factor 2
• SCN5A: sodium channel, voltage-gated, type V, alpha subunit
• SEPN1: selenoprotein N, 1
• SEPT9: septin 9
• SERPINA1: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
• SERPINC1: serpin peptidase inhibitor, clade C (antithrombin), member 1
• SH3BP2: SH3-domain binding protein 2
• SHANK3: SH3 and multiple ankyrin repeat domains 3
• SIL1: SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
• SIX1: SIX homeobox 1
• SIX5: SIX homeobox 5
• SLC5A1: solute carrier family 5 (sodium/glucose cotransporter), member 1
• SMAD4: SMAD family member 4
• SMC1A: structural maintenance of chromosomes 1A
• SMC3: structural maintenance of chromosomes 3
• SMN2: survival of motor neuron 2, centromeric
• SNCA: synuclein, alpha (non A4 component of amyloid precursor)
• SNCAIP: synuclein, alpha interacting protein
• SOD1: superoxide dismutase 1, soluble
• SOS1: son of sevenless homolog 1 (Drosophila)
• SOX10: SRY (sex determining region Y)-box 10
• SPAST: spastin
• SPG7: spastic paraplegia 7 (pure and complicated autosomal recessive)
• SRY: sex determining region Y
• STAT3: signal transducer and activator of transcription 3 (acute-phase response factor)
• STK11: serine/threonine kinase 11
• SUCLA2: succinate-CoA ligase, ADP-forming, beta subunit
• TAF1: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
• TBP: TATA box binding protein
• TBX1: T-box 1
• TBX5: T-box 5
• TCOF1: Treacher Collins-Franceschetti syndrome 1
• TEK: TEK tyrosine kinase, endothelial
• TFAP2B: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
• TGFB1: transforming growth factor, beta 1
• TGFBR2: transforming growth factor, beta receptor II (70/80kDa)
• TH: tyrosine hydroxylase
• TIMM8A: translocase of inner mitochondrial membrane 8 homolog A (yeast)
• TNXB: tenascin XB
• TOR1A: torsin family 1, member A (torsin A)
• TP53: tumor protein p53
• TRAPPC2: trafficking protein particle complex 2
• TRIOBP: TRIO and F-actin binding protein
• TSC1: tuberous sclerosis 1
• TSC2: tuberous sclerosis 2
• TSHB: thyroid stimulating hormone, beta
• TTN: titin
• TWIST1: twist homolog 1 (Drosophila)
• TYMP: thymidine phosphorylase
• TYR: tyrosinase (oculocutaneous albinism IA)
• TYROBP: TYRO protein tyrosine kinase binding protein
• TYRP1: tyrosinase-related protein 1
• UBE3A: ubiquitin protein ligase E3A
• UCHL1: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
• USH1C: Usher syndrome 1C (autosomal recessive, severe)
• USH2A: Usher syndrome 2A (autosomal recessive, mild)
• USP9Y: ubiquitin specific peptidase 9, Y-linked
• VAPB: VAMP (vesicle-associated membrane protein)-associated protein B and C
• VCP: valosin-containing protein
• VHL: von Hippel-Lindau tumor suppressor
• VLDLR: very low density lipoprotein receptor
• VPS13A: vacuolar protein sorting 13 homolog A (S. cerevisiae)
• VWF: von Willebrand factor
• WAS: Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
• WFS1: Wolfram syndrome 1 (wolframin)
• WRN: Werner syndrome, RecQ helicase-like
• XK: X-linked Kx blood group (McLeod syndrome)
• YARS: tyrosyl-tRNA synthetase
• YWHAE: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
• ZAP70: zeta-chain (TCR) associated protein kinase 70kDa
• ZEB2: zinc finger E-box binding homeobox 2

Source: Gene Ontology Consortium (June 2009).