html>* { 
	max-width: 121ex
	}

A { text-decoration:underline }
A:hover { color:#0000EE }
A:link { color:#0000EE }
A:visited { color:#551A8B } 
A.link-dapple SPAN { color:#000066 } 

A.twotone { text-decoration:none }
A.twotone SPAN.tone1 { color:#000066 }
A.twotone SPAN.tone2 { text-decoration:underline }


td.homebox-banner {margin-top:0em; margin-bottom:0em; padding-top:0em; padding-bottom:0em; background-color:#333399 }
td.homebox-banner-spotlight {margin-top:0em; margin-bottom:0em; padding-top:0em; padding-bottom:0em;  background-color:#cc6600}

td.homeboxbody li A { text-decoration: none }
td.homeboxbody li A:hover { text-decoration:underline }

A.rss { text-decoration: none }
A.rss:hover { text-decoration:underline }

td.homeboxbody ul { list-style-type: disc; color:#ffb73b }
td.homeboxbody li.More { list-style-type: disc; color:#333399 }

div.outerpith {background-color: white; margin-top:1ex}
body { background-color: #FFFFFF; color: #000066; margin-top:6px }
tbody th { font-weight:100; text-align:left; font-style:italic }
thead th { font-weight:bold; border-bottom-color:#ccccff; border-bottom-style:solid; border-bottom-width:1px; vertical-align:bottom; text-align:center; font-style:normal }
tr.rowheadings th { padding-bottom:0.5ex; padding-right:1em }
tr.rowheadings td { padding-bottom:0.5ex }
h1 {margin-top:0em; margin-bottom:0em }
div.allcontent {margin-left:6pt}
.offSiteImage {vertical-align:middle}
p {font-weight: 400; margin-top:1ex; margin-bottom:0pt}
ul li {font-weight: 400; margin-top:0pt}
div.h2content {margin-left:4ex}
div.h2contentN {}
.alphadivider {color:#ccccff; font-size:0.6em} 

li.sourcelink { margin-top:1ex }
li.othername { margin-top:0.1ex }

dd.mutationdescription { margin-top:1ex }

span.menu { }
span.glob2 { font-size:smaller; color:#996600 }
span.glob2bold { color:#996600; font-weight:bold }
.leftmenu {}
.footersmall {font-size: small}
.topictab1 {font-size: 1.3em; font-weight: 700; text-align:center; margin-top: 0em; margin-bottom: 0em}
.attribution { }
h2 { margin-top:14pt; color:#000066; font-size: 1.1em; margin-bottom:1ex}
h3 {font-size: 1em; font-weight: bold; color:#000099}

SPAN.searchType { font-weight: bold }
SPAN.searchSample { color:black; margin-top: 0em }
LI.spacedWidely { margin-top: 1ex }

span.searchErrorAnchorWord { text-decoration:underline } 

span.searchScore { margin-left:1em; color:#993300; font-style: italic; font-weight: bold }

span.glob { color:white }
A.glob:hover { color:white }
A.glob:link { color:white }
A.glob:visited { color:white }

span.trmenu { background-color:#996600 } 
A.glob2:hover { color:#996600 }
A.glob2:link { color:#996600 }
A.glob2:visited { color:#996600 }





div.leftbox { background-color:#Fafaff ; font-size:smaller}

div.leftboxtitle { display:none }

div.leftboxarea { border-top-width:1px; border-top-style:dotted; border-top-color:#551A8B; border-bottom-width:1px; border-bottom-style:dotted; border-bottom-color:#551A8B; padding-bottom:1ex; padding-top:1ex; padding-right:1ex }



ul.leftlinks_ul_bullet { margin-top:0ex; padding-left:20px; margin-left:0em }
ul.leftlinks_ul_bullet li { margin-top:1ex; list-style-image:url(/html/images/ActionTriangle.gif); margin-left:0em }
ul.leftlinks_ul_bullet dl { margin-top:0ex }
ul.leftlinks_ul_nobullet { margin-top:0ex; padding-left:0em; margin-left:0em }
ul.leftlinks_ul_nobullet li { margin-top:0ex; list-style-image:url(/html/images/blank1.gif); padding-left:0em; margin-left:1em; text-indent:-1em }
ul.leftlinks_ul_bullet li ul.leftlinks_ul_bullet { margin-top:0ex; padding-left:20px; margin-left:0em }
ul.leftlinks_ul_bullet li ul.leftlinks_ul_bullet li { margin-top:1ex; list-style-image:url(/html/images/ActionHollow1.png); margin-left:0em }

dd.leftmatter_dd { margin-left:1ex } 
dt.leftmatter_dt { margin-top:1ex }
span.leftmatter_disabled { color:#666699 }

span.typethis { font-family:monospace }
div.linkingToSampleBlock {margin-left:3em; margin-top:1ex; margin-bottom:1ex} 

ul.headroom li { margin-top:1ex }

p.top-search-sugg {
margin-top: 6pt; margin-bottom: 6pt; 
padding-left:6pt; padding-top:3pt; padding-bottom:3pt; 
border-top-style:solid; border-top-width:thin; 
border-bottom-style:solid; border-bottom-width:thin; 
border-left-style:solid; border-left-width:thin; 
border-right-style:solid; border-right-width:thin; 
background-color: #ffcc99; 
border-top-color:#ff9933; border-bottom-color:#ff9933; border-left-color:#ff9933; border-right-color:#ff9933; 
color:black
}
p.top-search-sugg A:link, p.top-search-sugg A:hover, p.top-search-sugg A:visited {
background-color:#ffcc99;
color:black
}

ul.glossarySynonyms li { list-style-type:circle } 
dl.glossaryDefinitions dt { margin-top: 1ex; display:list-item; list-style-type:disc } 

ul.home { margin-left:1ex; padding-left:1ex } 
ul.homewhatsnew { margin-left:2ex; padding-left:1ex; margin-bottom:0px; margin-top:2px } 
ul.homebrowse {margin-left:2ex; padding-left:1ex; margin-top:0; margin-bottom:1ex} 
div.homebrowsegene {margin-bottom:3pt; margin-left:1em} 
div.homebrowsegene ul {display:inline; padding-left:0em; margin-left:0em} 
div.homebrowsegene ul li {display:inline} 
ul.homezbot {margin-left:1ex; padding-left:1ex; margin-bottom:0pt; margin-top:2px} 
ul.homeresources {margin-left:1ex; padding-left:1ex; margin-bottom:6pt} 
ul.homelearn { margin-left:1ex; padding-left:1ex; margin-top:0pt; margin-bottom:0pt }
div.homebox-title  { font-weight:bold }
p.mt1ex {margin-top:1ex} 
tr.homeboxrow {} 
div.whatsnewmore { padding-top: 1ex} 
.homebox-title {  } 
.homebox-title a { color:#006 }
.homebox-title a:link { color:#006 }
.homebox-title a:visited { color:#006 }
.homebox-title a:hover { color:#006 }

h1.homebox-title { font-size:1em }

td.home-col-1 { vertical-align:top; width:30%}
td.home-col-2, td.home-col-3 {background-color: white}
td.home-col-2 { vertical-align:top; width:35%; border-left-width:0px;border-left-style:solid;border-left-color:#dddddd }
td.home-col-3 { vertical-align:top; width:35%; border-left-width:0px;border-left-style:solid;border-left-color:#dddddd }

td.home-col-2 td.homebox-bigbg , td.home-col-3 td.homebox-bigbg { border-width:1px; border-style:solid; border-color:#000066;  padding-right:1ex } 

td.home-col-1 td.homebox-bigbg-WhatsNewBox { border-bottom-width:1px; border-bottom-style:solid; border-bottom-color:#dddddd } 
td.home-col-1 td.homebox-bigbg-NewbornBox { border-bottom-width:1px; border-bottom-style:solid; border-bottom-color:#dddddd } 


p.home-hmug {margin-top:3pt; margin-bottom:3pt; font-weight:bold} 
img.home-pedigree {padding-left:1ex}

div.picpage_picturecaption { text-align: center } 
div.picpage_picturepicture { text-align: center } 

span.NEW2 {
color: #996600;
background-color: yellow;
font-weight: bold;
font-style: italic
}
 
div.glossaryleftbox div.leftboxtitle { background-color:#993399 }
div.glossaryleftbox div.leftboxarea { background-color:#f8f8f8; padding-bottom:1ex; padding-top:1ex; padding-right:1ex; border-color:#993399; border-width:1px; border-style:solid }
div.glossaryleftbox div.leftboxarea a:link {color:#666699}
div.glossaryleftbox div.leftboxarea ul { margin-top:0em; margin-bottom:0em; margin-left:0em; padding-left: 0em}
div.glossaryleftbox div.leftboxarea ul li { margin-left:0em; padding-left: 1em; list-style-image:url(/html/images/blank1.gif)}

div.chapterConceptTagline {margin-left:2em} 

div.ideogram { position:relative; margin-top:1em } 
div.ideogram img.ideogram { position:absolute; top:0 } 

span.withTooltip {cursor:default } 

div.hangingIndent { padding-left:1em; text-indent:-1em } 

hr.meek { width:10em; text-align:left; margin-left:0em; color:#ccccff }
p.whatsnewrss { text-indent:-45px; margin-left:45px; font-size:smaller }
.whatsnewdatehead {margin-bottom:0em} 
ul.whatsnewitems {margin-top:0em} 

div.topnext { float:right; position:relative }

*:target + h2 { color:black }
*:target + h3 { color:black }

.topnext A { color:#8080C0 }




div.dgc-toc ul { color:#aaaaee }

A.glref { text-decoration: none }
A.glref:hover { color:#000066 }

div.freepp ul li { margin-top:1ex }

div.glossary-breadcrumbs { margin-left:6pt; margin-bottom:0.5em; font-size:smaller }
div.topnextnav { position:relative; float:right; padding-top:0em } 
div.topnextantinav { position:relative; float:left; padding-top:0em } 
div.breadcrumbs .separator { font-size:1em; padding-left:1ex } 
div.breadcrumbs { text-align:center }
div.breadcrumbs .crumb { padding-left:1ex; white-space:nowrap }

hr.footerdivider {color:#006; background-color:#006; border-width:0px; height:2px} 

.info table .pad-left { padding-left:1ex }
.info table .pad-right { padding-right:1ex }
.info table caption { text-align:center; font-weight:bold; font-style:italic } 

div.dgc-toc { text-align:center; margin-bottom:8pt } 
div.dgc-toc .n-label { margin-right:1ex }
div.dgc-toc ul { display:inline; list-style-type:none; margin-left:0em; padding-left:0em } 
div.dgc-toc ul li { margin-right:1ex; display:inline; margin-left:0em; padding-left:0em }
div.dgc-toc p { display:inline; margin-right:1ex } 

dt { margin-top:1ex }

.search-details-synonyms { margin-left:1em }

div.search-result-doctype { text-indent: -1em }
div.search-result-snip { text-indent: -1em }
div.search-result-details { font-size:smaller; margin-left:3em }
div.search-result-gene-list { text-indent: -1em; color:#333 }
div.search-result-gene-list ul { display:inline; margin-left:1ex; padding-left:0 }
div.search-result-gene-list li { display:inline; margin-right:1ex }
div.search-result-gene-list li a { color:#333 }
div.search-result-gene-list li a:hover { color:#00e }
div.search-result-gene-list li a:link { color:#333 }
div.search-result-gene-list li a:visited { color:#551a8b }

span.search-result-article-type 
   { color: #494; font-size:smaller; white-space:nowrap } 
span.search-result-article-headline { margin-right:0.5em }

.search-results { margin-top:3pt }
.search-results li { margin-top: 8pt}

ul.search-word-suggestions { margin-top:3pt; margin-bottom:1em }
ul.search-word-suggestions li { display:inline; padding-left:2em; list-style-position:inside }
ul.search-word-suggestions a {  }

a.button { text-decoration: none } 

.homebox-searchForm-texta {
vertical-align:middle;
 background-color: white;
 border: 2px inset #996600;
 margin-top:0em; margin-bottom:0em; margin-right:0em; margin-left:0em;
}
.homebox-searchForm-btna {
vertical-align:middle;
border:2px outset #cc9933;
color:white; 
font-size:75%;
background-color:#cc9933; 
}


    #tabstrip {
      float:left; 
      width:100%;
      font-size:93%;
      line-height:normal;
      }
    #tabstrip ul {
      margin:0;
      padding:0 0 0 1px;
      list-style:none;
      }
    #tabstrip li {
      display:inline;
      margin:0;
      padding:0;
      }
    #tabstrip a {
      float:left;
      background-image:url("/html/images/tab-left.gif");
      background-repeat:no-repeat;
      background-position:left bottom;
      margin:0 0 0 -1px;
      padding:0 0 0 7px;
      text-decoration:none;
      }
    #tabstrip a span {
      float:left;
      display:block;
      background-image:url("/html/images/tab-rrright.gif");
      background-repeat:no-repeat;
      background-position:right bottom;
      padding:3px 7px 3px 0px;
      font-weight:bold;
      color:#006;
      }
    /* Commented Backslash Hack hides rule from IE5-Mac \*/
    #tabstrip a span {float:none;}
    /* End IE5-Mac hack */

    #tabstrip #current a {
      background-image:url("/html/images/tab-picked-left.gif");
      }
    #tabstrip #current a span {
      background-image:url("/html/images/tab-picked-rrright.gif");
      color:white;
      }

div.review-date-top {
        text-align:right; font-size:smaller; font-style:italic; margin-bottom: -6pt
}

ul.staff {list-style-type:none; margin-left:2em; text-indent:0em; padding-left:0em}

div.disease-abbr-div { text-align: center; margin-top: -1ex; margin-bottom:1em }
span.disease-abbr-envelope { font-style: italic }
span.disease-abbr { font-style: normal }

div.genefamily-fullname-div { margin-left: -1ex; text-align: center; margin-top: -1ex; margin-bottom:1em }
span.genefamily-fullname-envelope { font-style: italic }


sup.omim-footnote { font-style:italic } 

div.curation-level { margin-bottom: 1em; color: #339; font-size: smaller; padding: 0.5ex; text-align: center; border: solid thin #99c  } 

p.mimkey { text-indent: -2em; padding-left: 2em } 


div#details { margin-top: 1em } 

div#details:target { background-color: #dde  }


table.mimkey { } 
table.mimkey tbody tr td { padding-top: 1ex; padding-right: 1ex }
table.mimkey thead tr th { font-weight: 400; font-style: italic; padding-top: 1ex; padding-right: 1ex; vertical-align: bottom; text-align:left }
table.mimkey tbody tr th { padding-top: 1ex; padding-right: 1ex; vertical-align: bottom }
table.mimkey tbody tr td.mim-footnote-number {                   text-align: right; vertical-align: top }
table.mimkey tbody tr th.mim-footnote-number { font-weight: 400; text-align: right; vertical-align: top }
table.mimkey tbody tr td.mim-footnote-link   {                   text-align: left;  vertical-align: top}



p.resources-meme {
margin-top: 6pt; margin-bottom: 6pt; 
padding-left:6pt; padding-top:3pt; padding-bottom:3pt; padding-right:2pt;
border-top-style:solid; border-top-width:2px; 
border-bottom-style:solid; border-bottom-width:2px; 
border-left-style:solid; border-left-width:2px; 
border-right-style:solid; border-right-width:2px; 
border-color:#6b6;
color:#000066
}

tr.masthead-backdrop { background-color: #FFFFEE }
tr.masthead-service-of { background-color: #000066; color:white; font-size: smaller } 
tr.masthead-menu td { border-top-color:#000066; border-top-width:1px; border-top-style:solid } 

div.datestamp { font-size: smaller; font-style: italic } 

div#footer { font-size: smaller } 

.visuallyhidden {
   position:absolute;
   left:-10000px;
   top:auto;
   width:1px;
   height:1px;
   overflow:hidden;
}

blockquote.fund-lapse { font-size: x-large; color: black; background-color: white }

@media print {

    #tabstrip {
      display: none
      }

    div.noprint {display: none}
    span.noprint {display: none}
}

li.exploreqa {margin-top:1ex}

li.exploreqa div.exploreq {}

li.exploreqa xxdiv.explorea {margin-top:0.5em; margin-bottom:1em; padding-bottom: 2px}

li.exploreqa span.exploreal {vertical-align: super; display: inline-block}

li.exploreqa span.exploreaa {border-bottom: solid 2px black; display: inline-block; min-height: 1em}

span.exploref {margin-left: 1ex; border-bottom: solid 3px black; font-size: xx-large; display: inline-block; min-height: 1em; min-width:1em}
 
span.exploreff {margin-left: 1ex; font-size:8pt}

div.ghr-addthis {margin-top:1em} 
div.ghr-addthis-external-link-link-div {font-size: small; margin-bottom:1ex}
div.ghr-addthis-f-external-link-link-div {margin-bottom:0.5ex}
a.ghr-external-link-link-link {color:lightgray}
A.ghr-external-link-link-link:hover {color:gray}
A.ghr-external-link-link-link:link {color:gray} 
A.ghr-external-link-link-link:visited {color:gray} 

div.ghr-addthis-f {margin-top:1ex; text-align:center} 
div.ghr-addthis-f-external-link-link-div {font-size: small}
div.addthis_sharing_toolbox {height:24px}